Informatics Publishing Limited

M. Barathraj ¹, M. Arshath Michael ¹, P. Dinesh Kumar ¹, V. N. Vijay Kumar ¹, M. Reegan ¹, Sujitha ¹

Affiliations
1 Dr. M.G.R Educational and Research Institute University, Maduravoyal, Chennai-95, IN

Abstract

Mobile robots for search and rescue operations in hazardous environments have been actively studied in recent years One promising type of rescue robots is the so-called snake-like robot, which is typically composed of three or more segments that are connected serially. Because of the long and slender shape, snake-like robots are expected to be effective for searches in narrow spaces and over rubbles in quake-devastated regions, etc. In addition, snake-like robots for pipe inspection have been reported in the literature.

Keywords

Zigbee- IEEE 802.15.4, • Operating Frequencies 868,915 and 2400 MHz Frequencies, • Type of Communication Wireless Asynchronous Serial Communication, • Date Rate 250 kbps. Distance of Operation (80-100) Meters.

Full Text

     

C. R. Prakash ¹, S. Raja ², G. Saravanan ³, P. Dinesh Kumar ⁴, T. Panneer Selvam ⁵

Affiliations
1 Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu. Andhra Pradesh, IN
2 Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu, Andhra Pradesh, IN
3 Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), IN
4 Dep. of Pharmaceutics, Rahul Institute of Pharmaceutical Science and Research, Chirala-523157, (A.P.), IN
5 Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, IN

Abstract

In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH radical scavenging activity. In this method, the compound 3-(4-(4-dimethylaminobenzylideneamino) phenylimino) indoline-2-one (5c) showed highest antioxidant activity because of the presence of electron donating group.

Keywords

Antioxidant, Isatin, Schiff Base.

Full Text

     

P. Dinesh Kumar ¹, P. Vijayaraj Kumar ²

Affiliations
1 Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, IN
2 UCSI (University College Sadaya International) University, Jalan Menara Gading, 56000-Cheras, Kuala Lumpur,, MY

Abstract

Dendrimers represent a novel class of structurally controlled macromolecules derived from a braches upon branches structural motif. These consist of highly branched moieties that radiate from a central core and synthesizes through a stepwise repetitive reaction sequence. The structural advantage of dendrimers such as size, shape, surface and interior chemistry flexibility and topology by virtue are leads to play an important role in the field of nanotechnology, pharmaceutical and medicinal chemistry. Dendrimers have emerged as highly promising drug delivery molecule because of their unique structure and properties. Solubility enhancement is an important aspect of dendrimers and this is a synergy with site specific drug delivery. The hydrophobic guests when entrapped in the hydrophobic channels of dendrimers are solubilised in aqueous solution. Extracellular matrix of tissue particularly vascular tissue it contains a high concentration of negatively charged glycosaminoglycans which are involved in regulation of cell motility cell proliferation in the regulation of enzyme activity. Extra cellular matrix can be used as a substrate for binding and retention of drug delivered intra vascularly. Recently dendrimers have caused an explosion in biomedical science and created interest in the discovery of the drugs by virtue of their therapeutic value. The dendrimer polymer suggest that they are promising drugs wound healing ,bone mineralization cartilage formation, tissue repairing topical treatment for AIDS to prevent HIV transmission .It also acts as an anti prion, anti Alzheimer, anti coagulants, anti dots, anti inflammatory and anti cancer agents.

Keywords

Dendrimer, Nano-Composites, Dendrimer Conjugation, Dendrimer Applications.

Full Text

     

P. Dinesh Kumar ¹, L. Lakshman ², V. Alekhya ², B. Vijay Babu ²

Affiliations
1 Department of Pharmaceutics, Rahul Institute of Pharmaceutical Sciences & Research, Papaipalem Road, Kothepata, Chirala, 523157 Andhra Pradesh, IN
2 Department of Pharmaceutics, Rahul Institute of Pharmaceutical Sciences & Research, Chirala-523157, Andhra Pradesh, IN

Abstract

Lansoprazole is used for anti ulcer drug delivery. It is used to improve bioavailability and therapeutic efficacy of the drugs by using floating beads. When compared to other dosage forms it mainly treated diseases associated with the stomach. The retention of drug delivery systems will be resided in the stomach for longer time. The beads were prepared by using sterculia gum and sodium alginate acts as polymers and adds calcium chloride acts as cross linker. Mainly it is characterized by scanning electron microscopy, Fourier transform Infrared spectroscopy, beads size measurement and swelling studies. Invitro release dynamics of anti ulcer drug model lansoprazole from drug loaded beads in different media has been carried out for the evaluation of the drug release mechanism. These are the controlled drug delivery system with prolonged time in stomach.

Keywords

Lansoprazole, Floating Drug Delivery System, Floating Beads, Gastric Ulcer.

Full Text

     

P. Dinesh Kumar ¹, B. Rosiline Jeetha ²

Affiliations
1 Department of Computer Science, Dr. N.G.P. Arts and Science College, Coimbatore, IN
2 Department of Computer Science, Dr. N.G.P. Arts and Science College, Coimbatore, IN

Abstract

The detection of blood vessels from the retinal images is generally a slow process. Also, it is used to detect the diabetes in early stages by evaluating all the retinal blood vessels together. As digital imaging and computing power increasingly develop, so these technologies are used in ophthalmology. The main divisions include Image processing, Image analysis and Computer vision are increasingly becoming more prominence in all fields of medical science, and they are especially suited to the field of modern ophthalmology. Exciting developments in image processing relevant to ophthalmology over the past 15 years includes the progress being made towards developing a good solution for diseases such as diabetic retinopathy, age-related macular degeneration and retinopathy of prematurity. The quantitative measurements of retinal vascular topography using digital image analysis from retinal photography have been used as research tools to better understand the relationship between the retinal microvasculature and cardiovascular disease. Furthermore, advances in electronic media transmission increase the relevance of using image processing as an aid in clinical decision-making, with particular relevance to large rural-based communities. This paper mainly focuses on the phases involved in Retinal image processing and its concepts that can be more useful for the researcher’s to understand the basics.

Keywords

Retinal Image, Image Capture, Image Enhancement, Image Segmentation.

Full Text

     

T. Panneer Selvam ¹, G. Saravanan ², C. R. Prakash ³, P. Dinesh Kumar ⁴

Affiliations
1 Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, IN
2 Medicinal Chemistry Research Lab, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, IN
3 Department Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu-523167, Andhra Pradesh, IN
4 Department of Pharmaceutics, Rahul Institute of Pharmaceutical Science & Research, Chirala-523157, Andhra Pradesh, IN

Abstract

A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehyde 4a-e has been synthesized and tested for their anti-inflammatory and analgesic activities. Formation of the pyrazole derivatives was achieved by treating vilsmeier-haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to indomethacin, flufenamic acid and diazepam as standard drugs. The detailed synthesis, spectroscopic and toxicity data are reported.

Keywords

Pyrazole, Anti-Inflammatory Activity, Analgesic Activity.

Full Text

     

G. Saravanan ¹, V. Alagarsamy ², C. R. Prakash ¹, P. Dinesh Kumar ¹, T. Panneer Selvam ¹

Affiliations
1 Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522101, (A.P), IN
2 Medicinal Chemistry Research Laboratory, M.N.R. College of Pharmacy, Sangareddy-502294, (A.P), IN

Abstract

Thiazoles have a long history of having number of pharmacological activities such as anti-microbial, analgesic and anti-inflammatory activities. Pyrazoles shows promising anti-microbial, analgesic and anti-inflammatory activities. In the present study, novel thiazoles (8a - 8j) were synthesized by incorporation of pyrazole moiety at 2^nd position of 2-hydrazinyl-N-(4-phenylthiazol-2-yl) acetamide (5) by treating with chalcones (7a-7j). The chemical structures of the synthesized compounds were confirmed by means of IR, ¹H-NMR, Mass spectral and Elemental analysis. All the spectral data were consistent with the assigned structure. The synthesized compounds were investigated for analgesic activity by tail immersion method in mice. All the synthesized compounds exhibited mild to good analgesic activities. Among the synthesized compounds, 2-(5-(4-dimethylaminophenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4- phenylthiazol-2-yl) acetamide (8c) and 2-(5-(4-methylphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4-phenylthiazol- 2-yl) acetamide (8e) exhibited highest analgesic activity.

Keywords

Thiazole, Pyrazole, Chalcone and Analgesic Activity.

Full Text

     

A. R. Krishnaraja ¹, N. P. Sathishkumar ¹, T. Sathish Kumar ¹, P. Dinesh Kumar ¹

Affiliations
1 Department of Civil Engineering, Kongu Engineering College, Perundurai-638052, IN

Abstract

Utilisation of fly ash and Ground Granulated Blast Slag as an alternative material in concrete reduces the use of OPC in concrete. Evolution of geopolymer concrete cured at ambient temperature broadens its suitability and applicability to concrete based structures. This paper presents the mix proportions and outcome of an experimental study on the density and compressive strength of geopolymer concrete. Fly ash was used as a base material which was made to react with sodium hydroxide and sodium silicate solution to act as a binder for fine and coarse aggregate. Ground Granulated Blast Slag was replaced in different proportions to fly ash to enhance various properties of concrete. The concrete was subjected to curing at ambient temperature. Based on the study carried out, replacement of GGBS in fly ash up to 50% produced better mechanical properties.

Keywords

Concrete, Geopolymer, Ground Granulated Blast Slag, Ambient Curing.

Full Text

   

J. K. Patterson Edward ¹, G. Mathews ¹, K. Diraviya Raj ¹, R. L. Laju ¹, M. Selva Bharath ¹, A. Arasamuthu ¹, P. Dinesh Kumar ¹, Deepak S. Bilgi ², H. Malleshappa ³

Affiliations
1 Suganthi Devadason Marine Research Institute, 44-Beach Road, Tuticorin 628 001, IN
2 Gulf of Mannar Marine National Park, Ramanathapuram 623 503, IN
3 Department of Environment, Govt of Tamil Nadu, Chennai 600 015, IN

Abstract

Intensive underwater surveys have been conducted to assess the extent of coral bleaching and subsequent mortality in the Gulf of Mannar between March and October 2016. The extent of bleaching was 23.92% ± 10.55% during the period between March and June 2016, and the live coral cover was drastically reduced to 22.69 ± 9.07% during October 2016 with a mortality of 16.17 ± 8.46%. Fast-growing coral forms, including the genera Acropora, Montipora and Pocillopora were most affected, not only by bleaching but also by severe mortality. Boulders, including the genera Porites, Favia and Favites were found to be resistant to bleaching. During the bleaching period, water temperature was between 31.2°C and 32.6°C. The current bleaching is in alignment with the third global coral bleaching event which occurred between 2014 and 2017. Management interventions, including protection and rehabilitation using the native resistant coral species will not only help in the recovery process, but also increase the live coral cover.

Keywords

Bleaching, Climate Change, Coral Reefs, Mortality, Sea Surface Temperature.

Full Text

   

K. Prakash ¹, R. Kumar ², M. V. Venkatesan ², P. Dinesh Kumar ¹

Affiliations
1 Engineering Workshop, Larsen & Toubro Limited, IN
2 Larsen & Toubro Limited, IN

Abstract

Cracks developed in the 90 mm thick EN 10025-6 S550 QT steel plates assembled to form a box unit. After assembly the surface cracks generated longitudinally along the elongated grains while preheating or performing ischolar_main run. Root cause analysis was conducted to investigate the reason for the failure and also how to specify the “conditions of materials on delivery” during procurement is generated. Various tests such as visual test, chemical composition, inclusion rating, microstructure, dye penetrant test and hardness tests were conducted. The investigation revealed that the failure cracks could be due to temper embrittlement due to the segregations of impurities such as tin, arsenic, phosphorus and antimony, etc. in the grain boundaries and resulted in ductile to brittle transformation when exposed in the temperature. It is observed that, depends on the concentration of Ti and N in steel, coarse and cuboidal TiN particles of several micrometers in size act as potential sites for cleavage crack initiation. Furthermore, during the steel making process if sulfur is not properly controlled, then large MnS inclusions can also form during solidification. Soft MnS inclusions elongate during the subsequent hot rolling process, which deteriorate ductility and impact toughness. Hence, it is essential to specify the J factor value and inclusion rate during the procurement of steel.

Keywords

Inclusion Rate, Welding, Quenched Hardened Steel, Tempering, J-factor.

Full Text

     

P. Dinesh Kumar ¹

Affiliations
1 Department of Agriculture, Karunya University, Coimbatore 741 114, IN

Abstract

Sugarcane is a major cash crop in India, grown in almost 5 million hectares with a production of 339 million tonnes. Tamil Nadu contributes significantly to the production of sugarcane. Data from the past year show a huge fluctuation in the area and production of sugarcane in the state. Predicting the area and production employing traditional modelling techniques fails because the assumptions are never attained in the field. To overcome this, soft computing techniques like artificial neural networks (ANNs) are used. In this study, a multilayer perceptron neural network (MLP-NN) with back-propagation was used to predict the area and production of sugarcane in Tamil Nadu. The MLP-NN (2,2) model predicts the area with minimum mean absolute error (MAE; 18.139) and root mean squared error (RMSE; 23.058) values and with high accuracy (99%). For production, the MLP-NN (2,1) model estimates minimum MAE (24.875) and RMSE (31.199) values with high accuracy (99%). So, MLP-NN (2,2) and MLP-NN (2,1) are the best ANN models to predict the area and production of sugarcane in Tamil Nadu respectively. Additionally, ANN models perform better in predicting nonlinear stochastic data.

Keywords

Back Propagation, Multilayer Perceptron, Neural Network, Nonlinear Stochastic Data, Sugarcane Area and Production.

Full Text